Ever since his wife was burned in a car crash, Dr. Robert Ledgard (Antonia Banderas), an eminent plastic surgeon, has been interested in creating a new skin with which he could have saved her. After twelve years, he manages to cultivate a skin that is a real shield against every assault. In addition to years of study and experimentation, Robert needed a further three things: no scruples, an accomplice and a human guinea pig. Scruples were never a problem. Marilia, the woman who looked after him from the day he was born, is his most faithful accomplice. And as for the human guinea pig... Loosely based on Thierry Jonquet's 1995 novel "Mygale."